Head to the main bus terminal in León. Take a microbus from León to UCA microbus terminal in Managua. From there walk about 10 meters to the microbus heading to Granada. *Don’t be shocked if two companies start competing for your attention. There are two microbuses to Granada that sit next to each other and when the rule is that you leave only when full – your patronage is truly desired. I have literally been grabbed and pulled in two directions by two different people. Don’t worry, it’s more annoying than dangerous. They do it to almost everyone, including little old ladies.
Door to door this trip will take you from between 3.5hrs and 4.5hrs and will cost you (as of 03/16) 79 Cordobas.
Option 2: Do exactly as above but go by regular bus and save a little over $1 and use pass through the Mercado Roberto Huembes station instead.